CAS 222400-20-6

1654W9611T 222400-20-6 Tomopenem [USAN:INN] 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((3S,5S)-5-(((3S)-3-((((aminoiminomethyl)amino)acetyl)amino)-1-pyrrolidinyl)carbonyl)-1-methyl-3-pyrrolidinyl)thio)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-, (4R,5S,6S)- Tomopenem Antibiotic CS 023 Ro 4908463 R 115685 R 1558 (4R,5S,6S)-3-(((3S,5S)-5-(((3S)-3-((2-Guanidinoacetyl)amino)pyrrolidin-1-yl)carbonyl)-1-methylpyrrolidin-3-yl)sulfanyl)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid (4R,5S,6S)-3-(((3S,5S)-5-((3S)-3-(Carbamimidamidoacetamido)pyrrolidine-1-carbonyl)-1-methylpyrrolidin-3-yl)sulfanyl)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid CS-023 UNII-1654W9611T R-115685 R-1558 RO4908463

纯度 97%+现货药物标准品
CAS 号222400-20-6
分子式C23H35N7O6S
分子量537.63 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1654W9611T 222400-20-6 Tomopenem [USAN:INN] 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((3S,5S)-5-(((3S)-3-((((aminoiminomethyl)amino)acetyl)amino)-1-pyrrolidinyl)carbonyl)-1-methyl-3-pyrrolidinyl)thio)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-, (4R,5S,6S)- Tomopenem Antibiotic CS 023 Ro 4908463 R 115685 R 1558 (4R,5S,6S)-3-(((3S,5S)-5-(((3S)-3-((2-Guanidinoacetyl)amino)pyrrolidin-1-yl)carbonyl)-1-methylpyrrolidin-3-yl)sulfanyl)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid (4R,5S,6S)-3-(((3S,5S)-5-((3S)-3-(Carbamimidamidoacetamido)pyrrolidine-1-carbonyl)-1-methylpyrrolidin-3-yl)sulfanyl)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid CS-023 UNII-1654W9611T R-115685 R-1558 RO4908463 CAS 222400-20-6 结构式 Chemical Structure

产品介绍 Description

（1654W9611T 222400-20-6 Tomopenem [USAN:INN] 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((3S,5S)-5-(((3S)-3-((((aminoiminomethyl)amino)acetyl)amino)-1-pyrrolidinyl)carbonyl)-1-methyl-3-pyrrolidinyl)thio)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-, (4R,5S,6S)- Tomopenem Antibiotic CS 023 Ro 4908463 R 115685 R 1558 (4R,5S,6S)-3-(((3S,5S)-5-(((3S)-3-((2-Guanidinoacetyl)amino)pyrrolidin-1-yl)carbonyl)-1-methylpyrrolidin-3-yl)sulfanyl)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid (4R,5S,6S)-3-(((3S,5S)-5-((3S)-3-(Carbamimidamidoacetamido)pyrrolidine-1-carbonyl)-1-methylpyrrolidin-3-yl)sulfanyl)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid CS-023 UNII-1654W9611T R-115685 R-1558 RO4908463）是药物分析与质量控制领域常用的药物标准品，CAS 号 222400-20-6。分子式 C23H35N7O6S，分子量 537.63。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

（1654W9611T 222400-20-6 Tomopenem USAN:INN 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((3S,5S)-5-(((3S)-3-((((aminoiminomethyl)amino)acetyl)amino)-1-pyrrolidinyl)carbonyl)-1-methyl-3-pyrrolidinyl)thio)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-, (4R,5S,6S)- Tomopenem Antibiotic CS 023 Ro 4908463 R 115685 R 1558 (4R,5S,6S)-3-(((3S,5S)-5-(((3S)-3-((2-Guanidinoacetyl)amino)pyrrolidin-1-yl)carbonyl)-1-methylpyrrolidin-3-yl)sulfanyl)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)h

应用场景：在化学分析实验室中，（CAS 222400-20-6）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于阴凉处（≤25°C）保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称
分子式C23H35N7O6S
分子量537.63 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2020年
含氮原子数7
含硫原子数1

相关专利 Related Patents

  1. 发明人郑宇鹏，孙丽萍，杨光. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 108423932 B, 授权公告日 2018-08-09.
  2. 发明人赵玉洁，钱学锋，王建平. "Method for the Synthesis of 1654W9611T 222400-20-6 Tomopenem [USAN:INN] 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((3S,5S)-5-(((3S)-3-((((aminoiminomethyl)amino)acetyl)amino)-1-pyrrolidinyl)carbonyl)-1-methyl-3-pyrrolidinyl)thio)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-, (4R,5S,6S)- Tomopenem Antibiotic CS 023 Ro 4908463 R 115685 R 1558 (4R,5S,6S)-3-(((3S,5S)-5-(((3S)-3-((2-Guanidinoacetyl)amino)pyrrolidin-1-yl)carbonyl)-1-methylpyrrolidin-3-yl)sulfanyl)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid (4R,5S,6S)-3-(((3S,5S)-5-((3S)-3-(Carbamimidamidoacetamido)pyrrolidine-1-carbonyl)-1-methylpyrrolidin-3-yl)sulfanyl)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid CS-023 UNII-1654W9611T R-115685 R-1558 RO4908463" [P]. 中国发明专利, 专利号 CN 113173621 B, 授权公告日 2022-12-28.
  3. Yamamoto T, Thompson G K, Lee S K. "A Process for Preparing High-Purity 1654W9611T 222400-20-6 Tomopenem [USAN:INN] 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((3S,5S)-5-(((3S)-3-((((aminoiminomethyl)amino)acetyl)amino)-1-pyrrolidinyl)carbonyl)-1-methyl-3-pyrrolidinyl)thio)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-, (4R,5S,6S)- Tomopenem Antibiotic CS 023 Ro 4908463 R 115685 R 1558 (4R,5S,6S)-3-(((3S,5S)-5-(((3S)-3-((2-Guanidinoacetyl)amino)pyrrolidin-1-yl)carbonyl)-1-methylpyrrolidin-3-yl)sulfanyl)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid (4R,5S,6S)-3-(((3S,5S)-5-((3S)-3-(Carbamimidamidoacetamido)pyrrolidine-1-carbonyl)-1-methylpyrrolidin-3-yl)sulfanyl)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid CS-023 UNII-1654W9611T R-115685 R-1558 RO4908463" [P]. US Patent, US 10251019 B2, 2020-02-20.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Anal. Methods, 2012, 1803, 2489-2502.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Sci. Total Environ., 2022, 110, (5), 9857-9886.

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