(-)-2,3-<I>O</I>-异丙烯基-2,3-二羟基-1,4-双(二苯基膦)丁烷 CAS 32305-98-9
(4R,5R)-(-)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane 32305-98-9 (-)-1,4-BIS(DIPHENYLPHOSPHINO)-1,4-DIDEOXY-2,3-O-ISOPROPYLIDENE-L-THREITOL;(-)-2,3-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(-)-DIOP;(-)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(2R,3R)-(-)-1,4-BIS(DIPHENYLPHOSPHINO)-2,3-O-ISOPROPYLIDENE-2,3-BUTANEDIOL;(2R,3R)-(-)-2,3-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(2R,3R)-(-)-DIOP;(4R 5R)-(-)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(4R,5R)-(-)-2,2-DIMETHYL-4,5-BIS((DIPHENYLPHOSPHINO)METHYL)-1,3-DIOXOLANE;(4R,5R)-(-)-4,5-BIS(DIPHENYLPHOSPHINOMETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE;(4R,5R)-(-)-BIS(DIPHENYLPHOSPHINOMETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE;(4R,5R)-4,5-BIS(DIPHENYLPHOSPHINO-METHYL)-2,2-DIMETHYL-1,3-DIOXOLANE;(4R-TRANS)-[(2,2-DIMETHYL-1,3-DIOXOLANE-4,5-DIYL)BIS(METHYLENE)]BIS(DIPHENYLPHOSPHINE);(R,R)-DIOP SC11345
| CAS 号 | 32305-98-9 |
| 分子式 | C31H56O2P2 |
| 分子量 | 522.72 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
(-)-2,3-<I>O</I>-异丙烯基-2,3-二羟基-1,4-双(二苯基膦)丁烷（英文名 (4R,5R)-(-)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane 32305-98-9 (-)-1,4-BIS(DIPHENYLPHOSPHINO)-1,4-DIDEOXY-2,3-O-ISOPROPYLIDENE-L-THREITOL;(-)-2,3-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(-)-DIOP;(-)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(2R,3R)-(-)-1,4-BIS(DIPHENYLPHOSPHINO)-2,3-O-ISOPROPYLIDENE-2,3-BUTANEDIOL;(2R,3R)-(-)-2,3-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(2R,3R)-(-)-DIOP;(4R 5R)-(-)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(4R,5R)-(-)-2,2-DIMETHYL-4,5-BIS((DIPHENYLPHOSPHINO)METHYL)-1,3-DIOXOLANE;(4R,5R)-(-)-4,5-BIS(DIPHENYLPHOSPHINOMETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE;(4R,5R)-(-)-BIS(DIPHENYLPHOSPHINOMETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE;(4R,5R)-4,5-BIS(DIPHENYLPHOSPHINO-METHYL)-2,2-DIMETHYL-1,3-DIOXOLANE;(4R-TRANS)-[(2,2-DIMETHYL-1,3-DIOXOLANE-4,5-DIYL)BIS(METHYLENE)]BIS(DIPHENYLPHOSPHINE);(R,R)-DIOP SC11345，CAS 32305-98-9）属于药物标准品。分子式 C31H56O2P2，分子量 522.72。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
化学式为 C31H56O2P2 的(-)-2,3-<I>O</I>-异丙烯基-2,3-二羟基-1,4-双(二苯基膦)丁烷（(4R,5R)-(-)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane 32305-98-9 (-)-1,4-BIS(DIPHENYLPHOSPHINO)-1,4-DIDEOXY-2,3-O-ISOPROPYLIDENE-L-THREITOL;(-)-2,3-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(-)-DIOP;(-)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(2R,3R)-(-)-1,4-BIS(DIPHENYLPHOSPHINO)-2,3-O-ISOPROPYLIDENE-2,3-BUTANEDIOL;(2R,3R)-(-)-2,3-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DI
应用场景：在化学分析实验室中，(-)-2,3-<I>O</I>-异丙烯基-2,3-二羟基-1,4-双(二苯基膦)丁烷（CAS 32305-98-9）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以(-)-2,3-<I>O</I>-异丙烯基-2,3-二羟基-1,4-双(二苯基膦)丁烷配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用乙腈配制，于室温保存条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长
理化性质 Physical & Chemical Properties
| 中文名称 | (-)-2,3-<I>O</I>-异丙烯基-2,3-二羟基-1,4-双(二苯基膦)丁烷 |
| 分子式 | C31H56O2P2 |
| 分子量 | 522.72 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 室温保存 |
| 溶解性参考 | 可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 4.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1966年 |
相关专利 Related Patents
- Lefèvre J P, Martínez F, Sørensen M. "一种(-)-2,3-<I>O</I>-异丙烯基-2,3-二羟基-1,4-双(二苯基膦)丁烷的合成方法" [P]. European Patent, EP 3516860 A1, 2016-08-03.
- 发明人马晓峰，冯建国，韩伟. "Method for the Synthesis of (4R,5R)-(-)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane 32305-98-9 (-)-1,4-BIS(DIPHENYLPHOSPHINO)-1,4-DIDEOXY-2,3-O-ISOPROPYLIDENE-L-THREITOL;(-)-2,3-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(-)-DIOP;(-)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(2R,3R)-(-)-1,4-BIS(DIPHENYLPHOSPHINO)-2,3-O-ISOPROPYLIDENE-2,3-BUTANEDIOL;(2R,3R)-(-)-2,3-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(2R,3R)-(-)-DIOP;(4R 5R)-(-)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(4R,5R)-(-)-2,2-DIMETHYL-4,5-BIS((DIPHENYLPHOSPHINO)METHYL)-1,3-DIOXOLANE;(4R,5R)-(-)-4,5-BIS(DIPHENYLPHOSPHINOMETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE;(4R,5R)-(-)-BIS(DIPHENYLPHOSPHINOMETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE;(4R,5R)-4,5-BIS(DIPHENYLPHOSPHINO-METHYL)-2,2-DIMETHYL-1,3-DIOXOLANE;(4R-TRANS)-[(2,2-DIMETHYL-1,3-DIOXOLANE-4,5-DIYL)BIS(METHYLENE)]BIS(DIPHENYLPHOSPHINE);(R,R)-DIOP SC11345" [P]. 中国发明专利, 专利号 CN 109017841 B, 授权公告日 2016-02-03.
- 发明人李文辉，周伟，钱学锋. "A Process for Preparing High-Purity (4R,5R)-(-)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane 32305-98-9 (-)-1,4-BIS(DIPHENYLPHOSPHINO)-1,4-DIDEOXY-2,3-O-ISOPROPYLIDENE-L-THREITOL;(-)-2,3-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(-)-DIOP;(-)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(2R,3R)-(-)-1,4-BIS(DIPHENYLPHOSPHINO)-2,3-O-ISOPROPYLIDENE-2,3-BUTANEDIOL;(2R,3R)-(-)-2,3-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(2R,3R)-(-)-DIOP;(4R 5R)-(-)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(4R,5R)-(-)-2,2-DIMETHYL-4,5-BIS((DIPHENYLPHOSPHINO)METHYL)-1,3-DIOXOLANE;(4R,5R)-(-)-4,5-BIS(DIPHENYLPHOSPHINOMETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE;(4R,5R)-(-)-BIS(DIPHENYLPHOSPHINOMETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE;(4R,5R)-4,5-BIS(DIPHENYLPHOSPHINO-METHYL)-2,2-DIMETHYL-1,3-DIOXOLANE;(4R-TRANS)-[(2,2-DIMETHYL-1,3-DIOXOLANE-4,5-DIYL)BIS(METHYLENE)]BIS(DIPHENYLPHOSPHINE);(R,R)-DIOP SC11345" [P]. 中国发明专利, 专利号 CN 112852619 B, 授权公告日 2015-07-22.
参考文献 Literature
- Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of (-)-2,3-<I>O</I>-异丙烯基-2,3-二羟基-1,4-双(二苯基膦)丁烷 in Pharmaceutical Formulations". Sci. Total Environ., 2016, 937, 311-333.
- Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of (-)-2,3-<I>O</I>-异丙烯基-2,3-二羟基-1,4-双(二苯基膦)丁烷 as an Impurity". J. Pharm. Biomed. Anal., 2015, 1605, 9840-9863.
- Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of (4R,5R)-(-)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane 32305-98-9 (-)-1,4-BIS(DIPHENYLPHOSPHINO)-1,4-DIDEOXY-2,3-O-ISOPROPYLIDENE-L-THREITOL;(-)-2,3-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(-)-DIOP;(-)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(2R,3R)-(-)-1,4-BIS(DIPHENYLPHOSPHINO)-2,3-O-ISOPROPYLIDENE-2,3-BUTANEDIOL;(2R,3R)-(-)-2,3-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(2R,3R)-(-)-DIOP;(4R 5R)-(-)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS(DIPHENYLPHOSPHINO)BUTANE;(4R,5R)-(-)-2,2-DIMETHYL-4,5-BIS((DIPHENYLPHOSPHINO)METHYL)-1,3-DIOXOLANE;(4R,5R)-(-)-4,5-BIS(DIPHENYLPHOSPHINOMETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE;(4R,5R)-(-)-BIS(DIPHENYLPHOSPHINOMETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE;(4R,5R)-4,5-BIS(DIPHENYLPHOSPHINO-METHYL)-2,2-DIMETHYL-1,3-DIOXOLANE;(4R-TRANS)-[(2,2-DIMETHYL-1,3-DIOXOLANE-4,5-DIYL)BIS(METHYLENE)]BIS(DIPHENYLPHOSPHINE);(R,R)-DIOP SC11345 Using HRMS and NMR". Anal. Methods, 2023, 2136, (8), 1339-1359.
推荐产品 Recommended Standards
- (((4R,5R)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene))bis(dicyclohexylphosphine) (CAS 82239-68-7)
- 利马前列素杂质14 (CAS CATO-C4X-214514)
- (2S,3R,4R,5S,6R)-6-(acetoxymethyl)-3-(((2,2,2-trichloroethoxy)carbonyl)amino)tetrahydro-2H-pyran-2,4,5-triyl triacetate (CAS 122210-05-3)
- N-Isopropyl 4-bromo-3-methylbenzamide (CAS 1020252-77-0)
- 6-Methoxy-5-(trifluoromethyl)nicotinaldehyde (CAS 1211519-38-8)
- 2-((Tert-butoxycarbonyl)amino)-3-(2-hydroxyphenyl)propanoic acid (CAS 203569-04-4)
- 3-[4-(sec-Butyl)-2-chlorophenoxy]pyrrolidinehydrochloride (CAS 1220027-48-4)
- 2-(n-Methyl-1,2,5-thiadiazole-3-carboxamido)benzoic acid (CAS 1154306-32-7)
- Copper germanium selenide, 99.99% (metals basis) (CAS 54723-90-9)
- 司美格鲁肽杂质59 (CAS CATO-C4X-222659)
为什么选择 CATO 佳途？
- ISO 17034 / CNAS / ANAB 三重认证标准物质生产商
- 130,000+ 品种现货库存，支持 COA 定制
- 专业技术支持：+86 13829788188 / jacky.chen@cato-chem.com
- 全球 10,000+ 客户信赖之选