(<I>S</I>)-(+)-3-氨基-1-叔丁氧羰基哌啶 CAS 625471-18-3

(S)-3-Amino-1-N-BOC-piperidine (s)-1-boc-3-aminopiperidine (s)-tert-butyl 3-aminopiperidine-carboxylate (s)-3-amino-n-tboc-piperidine (s)-1-n-boc-3-aminopiperidine (s)-(+)-3-amino-1-boc-piperidine (s)-tert-butyl 3-aminopiperidine-1-carboxylate (s)-n-boc-3-aminopiperidine (3s)-3-aminopiperidine, n1-boc protected (s)-1-boc-3-amino-piperidine (s)-3-amino-1-boc-piperidine (s)3-amino-1-boc-piperidine (s)-1-boc-3-amniopiperidine (s)-3-amino-piperidine-1-carboxylic acid tert-butyl ester (s)-tert-butyl-3-aminopiperidine-1-carboxylate 1-piperidinecarboxylic acid, 3-amino-, 1,1-dimethylethyl ester, (3s)- 625471-18-3

纯度 97%+现货药物标准品
CAS 号625471-18-3
分子式C10H20N2O2
分子量200.28 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>S</I>)-(+)-3-氨基-1-叔丁氧羰基哌啶 (S)-3-Amino-1-N-BOC-piperidine (s)-1-boc-3-aminopiperidine (s)-tert-butyl 3-aminopiperidine-carboxylate (s)-3-amino-n-tboc-piperidine (s)-1-n-boc-3-aminopiperidine (s)-(+)-3-amino-1-boc-piperidine (s)-tert-butyl 3-aminopiperidine-1-carboxylate (s)-n-boc-3-aminopiperidine (3s)-3-aminopiperidine, n1-boc protected (s)-1-boc-3-amino-piperidine (s)-3-amino-1-boc-piperidine (s)3-amino-1-boc-piperidine (s)-1-boc-3-amniopiperidine (s)-3-amino-piperidine-1-carboxylic acid tert-butyl ester (s)-tert-butyl-3-aminopiperidine-1-carboxylate 1-piperidinecarboxylic acid, 3-amino-, 1,1-dimethylethyl ester, (3s)- 625471-18-3 CAS 625471-18-3 结构式 Chemical Structure

产品介绍 Description

CAS 625471-18-3 对应的(<I>S</I>)-(+)-3-氨基-1-叔丁氧羰基哌啶（(S)-3-Amino-1-N-BOC-piperidine (s)-1-boc-3-aminopiperidine (s)-tert-butyl 3-aminopiperidine-carboxylate (s)-3-amino-n-tboc-piperidine (s)-1-n-boc-3-aminopiperidine (s)-(+)-3-amino-1-boc-piperidine (s)-tert-butyl 3-aminopiperidine-1-carboxylate (s)-n-boc-3-aminopiperidine (3s)-3-aminopiperidine, n1-boc protected (s)-1-boc-3-amino-piperidine (s)-3-amino-1-boc-piperidine (s)3-amino-1-boc-piperidine (s)-1-boc-3-amniopiperidine (s)-3-amino-piperidine-1-carboxylic acid tert-butyl ester (s)-tert-butyl-3-aminopiperidine-1-carboxylate 1-piperidinecarboxylic acid, 3-amino-, 1,1-dimethylethyl ester, (3s)- 625471-18-3）为 CATO 佳途药物标准品产品线成员。分子式 C10H20N2O2，分子量 200.28。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 CAS编号 625471-18-3 对应的化合物(<I>S</I>)-(+)-3-氨基-1-叔丁氧羰基哌啶（英文标识 (S)-3-Amino-1-N-BOC-piperidine (s)-1-boc-3-aminopiperidine (s)-tert-butyl 3-aminopiperidine-carboxylate (s)-3-amino-n-tboc-piperidine (s)-1-n-boc-3-aminopiperidine (s)-(+)-3-amino-1-boc-piperidine (s)-tert-butyl 3-aminopiperidine-1-carboxylate (s)-n-boc-3-aminopiperidine (3s)-3-

应用场景：(<I>S</I>)-(+)-3-氨基-1-叔丁氧羰基哌啶（(S)-3-Amino-1-N-BOC-piperidine (s)-1-boc-3-aminopiperidine (s)-tert-butyl 3-aminopiperidine-carboxylate (s)-3-amino-n-tboc-piperidine (s)-1-n-boc-3-aminopiperidine (s)-(+)-3-amino-1-boc-piperidine (s)-tert-butyl 3-aminopiperidine-1-carboxylate (s)-n-boc-3-aminopiperidin

理化性质 Physical & Chemical Properties

中文名称(<I>S</I>)-(+)-3-氨基-1-叔丁氧羰基哌啶
分子式C10H20N2O2
分子量200.28 g/mol
外观形态白色至类白色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1985年
含氮原子数2

相关专利 Related Patents

  1. 发明人郭海燕，马晓峰，林芳. "一种(<I>S</I>)-(+)-3-氨基-1-叔丁氧羰基哌啶的合成方法" [P]. 中国发明专利, 专利号 CN 110577520 A, 授权公告日 2020-06-25.
  2. 发明人刘建华，郭海燕，陈志强. "Method for the Synthesis of (S)-3-Amino-1-N-BOC-piperidine (s)-1-boc-3-aminopiperidine (s)-tert-butyl 3-aminopiperidine-carboxylate (s)-3-amino-n-tboc-piperidine (s)-1-n-boc-3-aminopiperidine (s)-(+)-3-amino-1-boc-piperidine (s)-tert-butyl 3-aminopiperidine-1-carboxylate (s)-n-boc-3-aminopiperidine (3s)-3-aminopiperidine, n1-boc protected (s)-1-boc-3-amino-piperidine (s)-3-amino-1-boc-piperidine (s)3-amino-1-boc-piperidine (s)-1-boc-3-amniopiperidine (s)-3-amino-piperidine-1-carboxylic acid tert-butyl ester (s)-tert-butyl-3-aminopiperidine-1-carboxylate 1-piperidinecarboxylic acid, 3-amino-, 1,1-dimethylethyl ester, (3s)- 625471-18-3" [P]. 中国发明专利, 专利号 CN 109539726 A, 授权公告日 2023-02-11.
  3. Davis P L, Williams B T, Park J H. "A Process for Preparing High-Purity (S)-3-Amino-1-N-BOC-piperidine (s)-1-boc-3-aminopiperidine (s)-tert-butyl 3-aminopiperidine-carboxylate (s)-3-amino-n-tboc-piperidine (s)-1-n-boc-3-aminopiperidine (s)-(+)-3-amino-1-boc-piperidine (s)-tert-butyl 3-aminopiperidine-1-carboxylate (s)-n-boc-3-aminopiperidine (3s)-3-aminopiperidine, n1-boc protected (s)-1-boc-3-amino-piperidine (s)-3-amino-1-boc-piperidine (s)3-amino-1-boc-piperidine (s)-1-boc-3-amniopiperidine (s)-3-amino-piperidine-1-carboxylic acid tert-butyl ester (s)-tert-butyl-3-aminopiperidine-1-carboxylate 1-piperidinecarboxylic acid, 3-amino-, 1,1-dimethylethyl ester, (3s)- 625471-18-3" [P]. US Patent, US 11005439 B2, 2017-01-08.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>S</I>)-(+)-3-氨基-1-叔丁氧羰基哌啶 in Pharmaceutical Formulations". Sci. Total Environ., 2019, 1827, (10), 1960-1973.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>S</I>)-(+)-3-氨基-1-叔丁氧羰基哌啶 as an Impurity". Chemosphere, 2019, 1953, (2), 3829-3841.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of (S)-3-Amino-1-N-BOC-piperidine (s)-1-boc-3-aminopiperidine (s)-tert-butyl 3-aminopiperidine-carboxylate (s)-3-amino-n-tboc-piperidine (s)-1-n-boc-3-aminopiperidine (s)-(+)-3-amino-1-boc-piperidine (s)-tert-butyl 3-aminopiperidine-1-carboxylate (s)-n-boc-3-aminopiperidine (3s)-3-aminopiperidine, n1-boc protected (s)-1-boc-3-amino-piperidine (s)-3-amino-1-boc-piperidine (s)3-amino-1-boc-piperidine (s)-1-boc-3-amniopiperidine (s)-3-amino-piperidine-1-carboxylic acid tert-butyl ester (s)-tert-butyl-3-aminopiperidine-1-carboxylate 1-piperidinecarboxylic acid, 3-amino-, 1,1-dimethylethyl ester, (3s)- 625471-18-3 Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2018, 427, (10), 874-890.

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