樱草黄 CAS 8064-60-6

8064-60-6 Primuline Primuline, sodium salt (2,6':2',6''-Terbenzothiazole)-7-sulfonic acid, 2''-(4-aminophenyl)-6-methyl-, monosodium salt, mixt. with 2'-(4-aminophenyl)-6-methyl(2,6-bibenzothiazole)-7-sulfonic acid monosodium salt (2,6'-:2',6''-Terbenzothiazole)-7-sulfonic acid, 2''-(4-aminophenyl)-6-methyl-, monosodium salt, mixture with 2'-(4-aminophenyl)-6-methyl(2,6'-benzothiazole)-7-sulfonic acid, monosodium salt C.I. 49000 C.I. Direct Yellow 7, sodium salt Direct Yellow 59 NSC 72275 Primulinesulfonic acid Thioflavine S

纯度 97%+现货药物标准品
CAS 号8064-60-6
分子式C21H36N3O3S3 Na
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

樱草黄 8064-60-6 Primuline Primuline, sodium salt (2,6':2',6''-Terbenzothiazole)-7-sulfonic acid, 2''-(4-aminophenyl)-6-methyl-, monosodium salt, mixt. with 2'-(4-aminophenyl)-6-methyl(2,6-bibenzothiazole)-7-sulfonic acid monosodium salt (2,6'-:2',6''-Terbenzothiazole)-7-sulfonic acid, 2''-(4-aminophenyl)-6-methyl-, monosodium salt, mixture with 2'-(4-aminophenyl)-6-methyl(2,6'-benzothiazole)-7-sulfonic acid, monosodium salt C.I. 49000 C.I. Direct Yellow 7, sodium salt Direct Yellow 59 NSC 72275 Primulinesulfonic acid Thioflavine S CAS 8064-60-6 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的樱草黄（8064-60-6 Primuline Primuline, sodium salt (2,6':2',6''-Terbenzothiazole)-7-sulfonic acid, 2''-(4-aminophenyl)-6-methyl-, monosodium salt, mixt. with 2'-(4-aminophenyl)-6-methyl(2,6-bibenzothiazole)-7-sulfonic acid monosodium salt (2,6'-:2',6''-Terbenzothiazole)-7-sulfonic acid, 2''-(4-aminophenyl)-6-methyl-, monosodium salt, mixture with 2'-(4-aminophenyl)-6-methyl(2,6'-benzothiazole)-7-sulfonic acid, monosodium salt C.I. 49000 C.I. Direct Yellow 7, sodium salt Direct Yellow 59 NSC 72275 Primulinesulfonic acid Thioflavine S）为药物标准品，CAS 登记号 8064-60-6，分子式 C21H36N3O3S3 Na。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

依据分子式为 C21H36N3O3S3 Na 的樱草黄结构特征，其分子内含甾体骨架，酰胺类，含砜基，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 497.71 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 樱草黄（8064-60-6 Primuline Primuline, sodium salt (2,6':2',6''-Terbenzothiazole)-7-sulfonic acid, 2''-(4-aminophenyl)-6-methyl-, monosodium salt, mixt. with 2'-(4-aminophenyl)-6-methyl(2,6-bibenzothiazole)-7-sulfonic acid monosodium salt (2,6'-:2',6''-Terbenzothiazole)-7-sulfonic acid, 2''-(4-aminophenyl)-6-methyl-, monosodium salt, m

应用场景：樱草黄（8064-60-6 Primuline Primuline, sodium salt (2,6':2',6''-Terbenzothiazole)-7-sulfonic acid, 2''-(4-aminophenyl)-6-methyl-, monosodium salt, mixt. with 2'-(4-aminophenyl)-6-methyl(2,6-bibenzothiazole)-7-sulfonic acid monosodium salt (2,6'-:2',6''-Terbenzothiazole)-7-sulfonic acid, 2''-(4-aminophen

理化性质 Physical & Chemical Properties

中文名称樱草黄
分子式C21H36N3O3S3 Na
分子量497.71 g/mol
外观形态类白色至淡黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1959年
含氮原子数3
含硫原子数3

相关专利 Related Patents

  1. 发明人孙丽萍，沈红梅，胡光. "一种樱草黄的合成方法" [P]. 中国发明专利, 专利号 CN 114543142 B, 授权公告日 2022-02-13.
  2. Patel M V, Johnson M A, Yamamoto T. "Method for the Synthesis of 8064-60-6 Primuline Primuline, sodium salt (2,6':2',6''-Terbenzothiazole)-7-sulfonic acid, 2''-(4-aminophenyl)-6-methyl-, monosodium salt, mixt. with 2'-(4-aminophenyl)-6-methyl(2,6-bibenzothiazole)-7-sulfonic acid monosodium salt (2,6'-:2',6''-Terbenzothiazole)-7-sulfonic acid, 2''-(4-aminophenyl)-6-methyl-, monosodium salt, mixture with 2'-(4-aminophenyl)-6-methyl(2,6'-benzothiazole)-7-sulfonic acid, monosodium salt C.I. 49000 C.I. Direct Yellow 7, sodium salt Direct Yellow 59 NSC 72275 Primulinesulfonic acid Thioflavine S" [P]. US Patent, US 11778305 B2, 2016-01-18.
  3. Mueller T C, Lefèvre J P, Rossi M. "A Process for Preparing High-Purity 8064-60-6 Primuline Primuline, sodium salt (2,6':2',6''-Terbenzothiazole)-7-sulfonic acid, 2''-(4-aminophenyl)-6-methyl-, monosodium salt, mixt. with 2'-(4-aminophenyl)-6-methyl(2,6-bibenzothiazole)-7-sulfonic acid monosodium salt (2,6'-:2',6''-Terbenzothiazole)-7-sulfonic acid, 2''-(4-aminophenyl)-6-methyl-, monosodium salt, mixture with 2'-(4-aminophenyl)-6-methyl(2,6'-benzothiazole)-7-sulfonic acid, monosodium salt C.I. 49000 C.I. Direct Yellow 7, sodium salt Direct Yellow 59 NSC 72275 Primulinesulfonic acid Thioflavine S" [P]. European Patent, EP 3880153 A1, 2024-04-05.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 樱草黄 in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2022, 1523, (11), 1101-1117.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of 樱草黄 as an Impurity". Molecules, 2020, 1606, 4694-4705.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 8064-60-6 Primuline Primuline, sodium salt (2,6':2',6''-Terbenzothiazole)-7-sulfonic acid, 2''-(4-aminophenyl)-6-methyl-, monosodium salt, mixt. with 2'-(4-aminophenyl)-6-methyl(2,6-bibenzothiazole)-7-sulfonic acid monosodium salt (2,6'-:2',6''-Terbenzothiazole)-7-sulfonic acid, 2''-(4-aminophenyl)-6-methyl-, monosodium salt, mixture with 2'-(4-aminophenyl)-6-methyl(2,6'-benzothiazole)-7-sulfonic acid, monosodium salt C.I. 49000 C.I. Direct Yellow 7, sodium salt Direct Yellow 59 NSC 72275 Primulinesulfonic acid Thioflavine S Using HRMS and NMR". Talanta, 2011, 275, 5355-5363.

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